Search results for " Formation"
showing 10 items of 1920 documents
La politique de formation des ingénieurs en 1990
1999
Actes des XIXè journées de l'AES; International audience; Dans ce travail, il sera tenté de montrer que si les NFI (Nouvelles Formations d'Ingénieurs) constituent une réponse de la structure de formation (changement dans l'organisation de l'école) à un besoin externe (le monde économique), elles constituent aussi un ensemble de moyens que les acteurs sociaux définissent dans leur propre intérêt.
P3‐039: Axonal neuritic pathology induces early presynaptic alterations in ps1/APP Alzheimer's mice hippocampus
2011
Loss of neurons in the hippocampus correlates with memory impairment in AD. Significant early reduction in the numerical density of hippocampal SOM interneurons was found in single (APPswe) and double (APPswe/ PS1dE9 and APPswe/TauP301S-G272V) transgenic models based on APP over expression and amyloid production. However, this inhibitory population was unaffected in age-matched single PS1 and tau transgenic mice as well as nontransgenic controls. Whereas SOM neuron loss in APPswe/PS1dE9 was associated to the onset of extracellular amyloid pathology in double APP/ tau mice this loss preceded plaque formation. Conclusions: As in human AD, somatostatin cell loss is a common early pathological …
Pressure Shift and Gravitational Red Shift of Balmer Lines in White Dwarfs. Rediscussion
2015
The Stark-induced shift and asymmetry, the so-called pressure shift (PS) of $H_\alpha$ and $H_\beta$ Balmer lines in spectra of DA white dwarfs (WDs), as masking effects in measurements of the gravitational red shift in WDs, have been examined in detail. The results are compared with our earlier ones from before a quarter of a century (Grabowski et al. 1987, hereafter ApJ'87; Madej and Grabowski 1990). In these earlier papers, as a dominant constituent of the Balmer-line-profiles, the standard, symmetrical Stark line profiles, shifted as the whole by PS-effect, were applied to all spectrally active layers of the WD atmosphere. At present, in each of the WD layers, the Stark-line-profiles (e…
Transient oligemia is associated with long-term changes in binding densities of cortical inhibitory GABAA receptors in the rat brain
2009
Recently, we could demonstrate in rats that a short transient oligemic period of only 20-minute duration, induced by systemic hypotension, resulted in a transient decline of spatial memory capacities without any histological damage over a subsequent period of 6 months. In our present study, we checked for more subtle alterations within the highly vulnerable hippocampal CA1 subfield using quantification of neuronal cell density and semi-quantitative analysis of the ischemia-sensitive protein MAP2. Since hippocampal excitatory and inhibitory neurotransmitter receptors are crucially involved in spatial memory processes, quantitative in vitro receptor autoradiography was performed using [(3)H]M…
Stimulatory and inhibitory effects of ethanol on hippocampal acetylcholine release
1998
Using the microdialysis technique and sensitive HPLC procedures for the determination of acetylcholine (ACh) and ethanol, we investigated the release of ACh in rat hippocampus after acute ethanol administration. Systemic administration of ethanol (0.8 and 2.4 g/kg i.p.) led to peak ethanol concentrations of 21 and 42 mM in the hippocampus, respectively. The high dose caused a long-lasting inhibition of basal ACh release by up to 33%. Local infusion of scopolamine (1 microM) enhanced hippocampal ACh release up to eightfold in the presence of neostigmine (10 microM), and this stimulated release was also inhibited after systemic ethanol administration (by up to 45%). The low dose of ethanol (0…
Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety,…
2011
Intensive research is devoted to unravel the neurobiological mechanisms mediating adult hippocampal neurogenesis, its regulation by antidepressants, and its behavioral consequences. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that is expressed in the CNS, where its function is unknown. Here, we show, for the first time, the relevance of MIF expression for adult hippocampal neurogenesis. We identify MIF expression in neurogenic cells (in stem cells, cells undergoing proliferation, and in newly proliferated cells undergoing maturation) in the subgranular zone of the rodent dentate gyrus. A causal function for MIF in cell proliferation was shown using genetic (M…
The Gaia-ESO Survey: The origin and evolution of s-process elements
2018
Context. Several works have found an increase of the abundances of the s-process neutron-capture elements in the youngest Galactic stellar populations. These trends provide important constraints on stellar and Galactic evolution and they need to be confirmed with large and statistically significant samples of stars spanning wide age and distance intervals. Aims. We aim to trace the abundance patterns and the time evolution of five s-process elements - two belonging to the first peak, Y and Zr, and three belonging to the second peak, Ba, La, and Ce - using the Gaia-ESO IDR5 results for open clusters and disc stars. Methods. From the UVES spectra of cluster member stars, we determined the ave…
Spatial localization and pattern formation in discrete optomechanical cavities and arrays
2020
We investigate theoretically the generation of nonlinear dissipative structures in optomechanical (OM) systems containing discrete arrays of mechanical resonators. We consider both hybrid models in which the optical system is a continuous multimode field, as it would happen in an OM cavity containing an array of micro-mirrors, and also fully discrete models in which each mechanical resonator interacts with a single optical mode, making contact with Ludwig & Marquardt [Phys. Rev. Lett. 101, 073603 (2013)]. Also, we study the connections between both types of models and continuous OM models. While all three types of models merge naturally in the limit of a large number of densely distribu…
In Vitro Cytokine Production by HLA-B8, DR3 Positive Subjects
1994
It is well known that healthy subjects carrying the HLA-B8,DR3 haplotype may show an impairment of immune system, the T cells being the most affected. To gain insight into the mechanism(s) of the impairment displayed by these subjects, efforts have been centered on the study of in vitro cytokine production because of the pivotal role played by these mediators in the activation and control of several immune functions. The available results indicate that the ability to several immune functions. The available results indicate that the ability to produce interleukin-1 (IL-1), IL-2 and the soluble form of its receptor (sIL-2R) is impaired in HLA-B8,DR3 positive healthy subjects. To better charac…
A computer-assisted experiment to study the influence of the point spread function in the image formation process
2018
[EN] We present a new open experimental setup assisted with LabView to be used to teach the concept of the point spread function (PSF). The PSF describes the response of an image-forming system to a point object. The PSF concept is of fundamental importance in optics since the output of an image-forming system can be simulated as the convolution of the PSF with the input object. In this work, a new graphical user interface has been developed to obtain a real-time measure of the PSF and the corresponding images provided by different lenses and pupils with different sizes and shapes. From a didactical point of view, the proposed method allows students to interpret the results in a visual and …